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KMID : 0379519870030010055
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한국독성학회지
1987 Volume.3 No. 1 p.55 ~ p.63
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PERI-NATAL AND POST-NATAL STUDY OF THE RECOMBINANT HUMAN INTERFERON {alpha}A;(rHuIFN-{alpha}A) IN RATS
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Lee Yong-Soon
Kim Yun-Bae
Kim Hyun-Su
Cho Nam-Jin
Yoo Moo-Young
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Abstract
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A Peri-and Postnatal Study was Carried out to examine the effects of rHuIFN-{alpha}A, produced by gene-manipulated E. coli, on offsprings of Wistar rats. The substance was administered intraperitoneally to dams at dose levels of 1{times}10^5, 4{times}10^5 and 1.2{times}10^6 I.U/kg/day during the period from day 17 of gestation to day 21 after delivery. All the pregnant dams were allowed to deliver naturally, and the postnatal development of the offsprings was observed. No noticeable toxic effects and pathological changes on dams were observed, and no detectable variations in postnatal development of offsprings occured.
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KEYWORD
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rHuIFN-{alpha}A, peri-and postnatal study
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